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Succinic semialdehyde dehydrogenase deficiency can be a condition that causes GHB to build up while in the blood.Cells create GHB by reduction of succinic semialdehyde by way of succinic semialdehyde reductase (SSR). This enzyme seems to get induced by cAMP concentrations,[80] this means substances that elevate cAMP, including forskolin and vinpoce